Blog icon

The challenge

Reducing the likelihood of implant rejection and infection

Hundreds of thousands of Australians receive medical implants like bone replacements, catheters and pacemakers every year. The human body is a complex system so there is a lot to consider when implanting artificial parts. Reducing the likelihood of infection and ensuring the body doesn't reject implants present ongoing medical challenges.

[Music plays and text appears on screen: Better implants inspired by the beginnings of life]   

[Image changes to show an animation of Earth] 

Narrator: The beginning of the little green and blue ball we call home, started with the big bang. 

[Image changes to show an animation of Earth and a red explosion over it] 

When planet Earth was created, it was a pretty hostile place. 

[Image changes to show an animation of a volcano with smoke pluming from it] 

There was some water and some gases, but that was about it. 

[Image changes to show an animation of a scientist pondering and four animals pop up behind him, a monkey, a frog, a lizard and a fish]So where did life come from I hear you ask? 

[Image changes to show an animation of a pool of goo and inside green and yellow circles, representing the molecules, are popping up inside it] 

Well prebiotic chemists think it all happened when the molecules got together in the primordial goo that existed when the planet formed.  

[Camera zooms in on the molecules as they adapt and transform]  

These molecules, like amino acids, adapted and transformed. They got stronger and more complex. Amino acids, were the building blocks of future of peptides and proteins, which all lead to RNA[Image changes to show an animation of a DNA strand] then DNA and that was the beginning of life on Earth.   

[Image changes back to show the animation of Earth with the scientist standing beside it]  

Now this got our scientists thinking that this primordial goo must have been pretty impressive stuff.  

[Image changes to show the animation of the goo with the scientist standing beside it]   

But they wondered how it could be used practically to solve a real world problem. 

[Image changes to show an animation of beakers and test tubes with a whiteboard in the background with written equations on it] 

By employing the techniques of the prebiotic chemists they created a version of primordial goo and they discovered it could form a coating, it is adhesive and coats almost any material surface. 

[Image changes to show an animation of the goo being transformed into the products as the narrator describes above] 

From there they added other molecules and discovered that this could have some real applications for the biomedical industry.  

[Image changes to show an animation of molecules, a magnifying glass pans over them and enlarges them behind the glass]  

Their research shows that the coating can be applied to medical devices, including catheters or implants for bone replacements, 

[Image changes to show an animation of a female figure placing an X-ray board in front of her so you can see her skeleton]  

this could have a range of uses to make implants better by making them antibacterial or more compatible with the human body. 

[Image changes to show an animation of the scientist pouring goo from a green beaker into another container labelled Research] 

This kind of coating is also much cheaper and easier to apply than current biomedical coatings, potentially helping tens of thousands of implant recipients per year in Australia alone.  

[Image changes to show an animation of a female figure wheeling a drip on a trolley. Dark shadows of rows of people appear behind her representing other recipients of implants]  

All inspired by the beginnings of life on Earth.  

[Image changes back to the animation of Earth] 

We’ve sure come a long way from primordial goo. 

[Image changes to show an animation of the goo with the scientist standing beside the pool of goo holding a sample in a test tube]  

[Music plays and CSIRO logo appears on screen with text: Big ideas start here

Share & embed this video



Embed code

<iframe src="//" width="640" height="360" frameborder="0" allow="autoplay; fullscreen" allowfullscreen></iframe>


Our response

A prebiotic solution, billions of years in the making

The prebiotic compounds found in 'goo', which are believed to have been the source of all life evolving on Earth, can be traced back billions of years and have been studied intensively since their discovery several decades ago.

Our scientists wanted to see if they could apply the chemistry of this 'goo' in a practical way, and for the first time uncovered a method for using prehistoric molecules to assist with medical treatments.

The team developed a bio-friendly coating that allows cells to readily grow and colonise.

The results

Better coatings for implants

The coating process developed by the scientists is very simple and uses methods and substances that are readily available, meaning biomedical manufacturers can produce improved results more cost effectively compared to existing coatings.

The non-toxic coating is adhesive and will coat almost any material making its potential biomedical applications broad. It can be applied to medical devices to improve their performance and acceptance by the body, and can assist with a range of medical procedures.

CSIRO is the first organisation to investigate practical applications of this kind using prebiotic chemistry. The research opens the door to a host of new biomedical possibilities that are still yet to be explored.

CSIRO is seeking to partner with biomedical manufacturers to exploit this technology.

You can read more about this in the Nature journal, Asia Materials, available at Prebiotic-chemistry inspired polymer coatings for biomedical and material science applications.

Do business with us to help your organisation thrive

We partner with small and large companies, government and industry in Australia and around the world.

Contact us now to start doing business

Contact us

Find out how we can help you and your business. Get in touch using the form below and our experts will get in contact soon!

CSIRO will handle your personal information in accordance with the Privacy Act 1988 (Cth) and our Privacy Policy.

First name must be filled in

Surname must be filled in

I am representing *

Please choose an option

Please provide a subject for the enquriy

0 / 100

We'll need to know what you want to contact us about so we can give you an answer

0 / 1900

You shouldn't be able to see this field. Please try again and leave the field blank.